反应详情

Compound 44 (181 mg, 0.50 mmol), 2-chloro-5-cyanopyridine (104 mg, 0.75 mmol) and potassium carbonate (207 mg, 1.50 mmol) were suspended in 1,4-dioxane (4 mL), followed by stirring overnight under heating and reflux. The insoluble was removed through filtration, the filtrate was distilled away under reduced pressure, and the resulting residue was purified through silica gel column chromatography (chloroform:methanol=20:1) to afford the entitled Compound 45 (158 mg, 68%).

1. temperatureunder heating
2. temperaturereflux
3. customThe insoluble was removed through filtration
4. distillationthe filtrate was distilled away under reduced pressure
5. customthe resulting residue was purified through silica gel column chromatography (chloroform:methanol=20:1)