Ethyl Acetoacetate → Butanoic acid, 3-hydroxy-, ethyl ester, (3S)-

HRID 2239208Notes

Reaction equation

HRID 2239208 reaction equation
[C:1]([O:7][CH2:8][CH3:9])(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4]>O>[OH:4][C@@H:3]([CH3:5])[CH2:2][C:1]([O:7][CH2:8][CH3:9])=[O:6]

Participants

3

Reactant 1

HCID 8868Ethyl Acetoacetate

Product 1

HCID 6950306Butanoic acid, 3-hydroxy-, ethyl ester, (3S)-Yield 80%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Ethyl acetoacetate (130 mg, 1 mmol) was reacted with yeast (2 g) and water (2 ml) according to method I. Extraction of the yeast gave the pure product in 80% yield. The reaction was repeated following the general procedure of Method II outlined above to yield a pure product in 78% yield.

Workup

  1. extractionExtraction of the yeast
  2. customgave the pure product in 80% yield
  3. customto yield a pure product in 78% yield

Sources & evidence

ORD record
ord-e6294882cd584d2eb4a6d33d9d136cfd
Source dataset
uspto-grants-2010_05
Patent number
US07723065B2

Reaction notes

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