Triethylene glycol monomethyl ether → HCID 67201661, compound

HRID 2239226Notes

Reaction equation

HRID 2239226 reaction equation
C1CCC(N=C=NC2CCCCC2)CC1.[CH:16]([C:18]1[CH:26]=[CH:25][C:21]([C:22]([OH:24])=[O:23])=[CH:20][CH:19]=1)=[CH2:17].[CH3:27][O:28][CH2:29][CH2:30][O:31][CH2:32][CH2:33][O:34][CH2:35][CH2:36]O>CN(C1C=CN=CC=1)C>[CH:16]([C:18]1[CH:26]=[CH:25][C:21]([C:22]([O:24][CH2:36][CH2:35][O:34][CH2:33][CH2:32][O:31][CH2:30][CH2:29][O:28][CH3:27])=[O:23])=[CH:20][CH:19]=1)=[CH2:17]

Participants

5

Reactant 3

HCID 8178Triethylene glycol monomethyl etherHCID 10868DicyclohexylcarbodiimideHCID 140984-Vinylbenzoic acid

Product 1

HCID 67201661HCID 67201661, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 142844-(Dimethylamino)pyridineCatalyst

Procedure

As described in Example 6a) the compound was obtained by reacting together DCC (3.1 g, 14.9 mmol), 4-vinylbenzoic acid (2.0 g, 13.5 mmol), DMAP (1.3 g, 10.8 mmol) and 2-[2-(2-methoxyethoxy)ethoxy]ethanol (3.3 g, 20.3 mmol) for 2 days. Flash-chromatography over SiO2 (heptane/ether gradient) and drying under high vacuum gave 3.1 g of a slightly yellow oil (yield: 78%).

Workup

  1. customwas obtained
  2. customfor 2 days
  3. customFlash-chromatography over SiO2 (heptane/ether gradient) and drying under high vacuum

Sources & evidence

ORD record
ord-612c156dc659417bb3af54e6c64320f1
Source dataset
uspto-grants-2010_05
Patent number
US07723286B2

Reaction notes

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