3-[3-(4-Ethyl-2,2,7-trimethyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-4-trifluoromethoxy-phenyl]-acrylic acid tert-butyl ester → 3-[3-(4-Ethyl-2,2,7-trimethyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-4-(2,2,2-trifluoro-ethoxy)-phenyl]-acrylic acid tert-butyl ester

HRID 2239245Notes

Reaction equation

HRID 2239245 reaction equation
[CH2:1]([N:3]1[C:8]2[CH:9]=[C:10]([C:14]3[CH:15]=[C:16]([CH:19]=[CH:20][C:21]=3[O:22][CH2:23][C:24]([F:27])([F:26])[F:25])C=O)[C:11]([CH3:13])=[CH:12][C:7]=2[O:6][C:5]([CH3:29])([CH3:28])[C:4]1=[O:30])[CH3:2].[C:31]([O:35][C:36](=[O:66])[CH:37]=[CH:38]C1C=CC(OC(F)(F)F)=C(C2C(C)=CC3OC(C)(C)C(=O)N(CC)C=3C=2)C=1)([CH3:34])([CH3:33])[CH3:32]>>[C:31]([O:35][C:36](=[O:66])[CH:37]=[CH:38][C:16]1[CH:19]=[CH:20][C:21]([O:22][CH2:23][C:24]([F:25])([F:27])[F:26])=[C:14]([C:10]2[C:11]([CH3:13])=[CH:12][C:7]3[O:6][C:5]([CH3:28])([CH3:29])[C:4](=[O:30])[N:3]([CH2:1][CH3:2])[C:8]=3[CH:9]=2)[CH:15]=1)([CH3:34])([CH3:33])[CH3:32]

Participants

3

Reactant 2

HCID 685832583-[3-(4-Ethyl-2,2,7-trimethyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-4-trifluoromethoxy-phenyl]-acrylic acid tert-butyl esterHCID 866116783-(4-Ethyl-2,2,7-trimethyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-4-(2,2,2-trifluoro-ethoxy)-benzaldehyde

Product 1

HCID 685827203-[3-(4-Ethyl-2,2,7-trimethyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-4-(2,2,2-trifluoro-ethoxy)-phenyl]-acrylic acid tert-butyl ester

Procedure

This was made from Compound 2C using a procedure similar to that described for Compound 1E. MS (electrospray): mass calculated for C28H32F3NO5, 519.2; m/z found 520.2, [M+H]+.

Sources & evidence

ORD record
ord-3a6bd675653e404eb01feffb25355bf1
Source dataset
uspto-grants-2010_05
Patent number
US07723326B2

Reaction notes

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