HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Ethanediamine, N1,N1,N2-trimethyl- → 4-[(5,7-Difluoro-3,4-dihydro-2H-chromen-4-yl)oxy]-N-[2-(dimethylamino)ethyl]-N,2-dimethyl-1H-benzimidazole-6-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Ethanediamine, N1,N1,N2-trimethyl- | HCID 67338 | — |
| Reactant | 7-[(5,7-Difluorochroman-4-yl)oxy]-2-methyl-1H-benzo[d]imidazole-5-carboxylic Acid | HCID 68574559 | — |
| Product | 4-[(5,7-Difluoro-3,4-dihydro-2H-chromen-4-yl)oxy]-N-[2-(dimethylamino)ethyl]-N,2-dimethyl-1H-benzimidazole-6-carboxamide | HCID 58900197 | 13% |
Reaction Steps
The title compound was prepared as a white solid (10 mg, 13% yield for 3 steps) from 4-[(5,7-difluoro-3,4-dihydro-2H-chromen-4-yl)oxy]-2-methyl-1H-benzimidazole-6-carboxylic acid (100 mg, crude, STEP 4 in Example 4) and N,N,N′-trimethyl-1,2-ethanediamine (45 mg, 0.44 mmol) by the same manner in STEP 5 of Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07723321B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-f97bf719ed8740eb9c19bdd8c3cb8339 |
| Source note | uspto-grants-2010_05 |