HCID 65751601, compound → HCID 58900208, compound

HRID 2239315Notes

Reaction equation

HRID 2239315 reaction equation
[CH3:1][N:2]([CH3:23])[C:3]([C:5]1[CH:6]=[C:7]([OH:22])[C:8]2[N:12]=[C:11]([CH3:13])[N:10](C(OC(C)(C)C)=O)[C:9]=2[CH:21]=1)=[O:4].[F:24][C:25]1[CH:26]=[CH:27][C:28]([CH3:36])=[C:29]2[C:34]=1[O:33][CH2:32][CH2:31][CH:30]2O>>[F:24][C:25]1[CH:26]=[CH:27][C:28]([CH3:36])=[C:29]2[C:34]=1[O:33][CH2:32][CH2:31][CH:30]2[O:22][C:7]1[C:8]2[N:12]=[C:11]([CH3:13])[NH:10][C:9]=2[CH:21]=[C:5]([C:3]([N:2]([CH3:1])[CH3:23])=[O:4])[CH:6]=1

Participants

3

Reactant 2

HCID 65751601HCID 65751601, compoundHCID 68574581HCID 68574581, compound

Product 1

HCID 58900208HCID 58900208, compoundYield 32%

Procedure

The title compound was prepared as a white solid in 32% yield (38 mg) from 1,1-dimethylethyl 6-[(dimethylamino)carbonyl]-4-hydroxy-2-methyl-1H-benzimidazole-1-carboxylate (100 mg, 0.31 mmol, STEP 2 in Example 9) and 8-fluoro-5-methylchroman-4-ol (0.23 g, 1.2 mmol, STEP 1-3) by the same manner in STEP 3-2 of Example 9.

Sources & evidence

ORD record
ord-da1a817d84be4b0892de5a524f3ab736
Source dataset
uspto-grants-2010_05
Patent number
US07723321B2

Reaction notes

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