Methylamine → HCID 68481117, compound

HRID 2239440Notes

Reaction equation

HRID 2239440 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][C:3]=1[F:12].[CH3:13][NH2:14]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:14][CH3:13])(=[O:10])=[O:9])=[CH:4][C:3]=1[F:12]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 27782184-Bromo-3-fluorobenzenesulfonyl chloride

Product 1

HCID 68481117HCID 68481117, compoundYield 85%

Procedure

According to general procedure A, 4-Bromo-3-fluoro-benzenesulfonyl chloride (0.40 g, 1.46 mmol) and methylamine (10 mL, 33% in ethanol) were stirred together for 16 hours. 4-bromo-3-fluoro-N-methylbenzenesulfonamide (0.33 g, 85%) was provided after purification. HRMS: calcd for C7H7BrFNO2S, 266.93649; found (EI, M+.), 266.9376. HPLC purity 100.0% at 210-370 nm, 8.7 min.; the Xterra® RP18 column, 3.5μ, 150×4.6 mm column, 1.2 mL/min., 85/15-5/95 (ammonium formate buffer pH=3.5/ACN+MeOH) for 10 min., hold 4 min.

Sources & evidence

ORD record
ord-b29a3330002b4947a73e0ac661aae57f
Source dataset
uspto-grants-2010_05
Patent number
US07723332B2

Reaction notes

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