Cyclobutylamine → HCID 68484532, compound

HRID 2239458Notes

Reaction equation

HRID 2239458 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][C:3]=1[F:12].[CH:13]1([NH2:17])[CH2:16][CH2:15][CH2:14]1>ClCCl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:17][CH:13]2[CH2:16][CH2:15][CH2:14]2)(=[O:10])=[O:9])=[CH:4][C:3]=1[F:12]

Participants

4

Reactant 2

HCID 75645CyclobutylamineHCID 27782184-Bromo-3-fluorobenzenesulfonyl chloride

Product 1

HCID 68484532HCID 68484532, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

According to general procedure C, 4-Bromo-3-fluoro-benzenesulfonyl chloride (0.40 g, 1.46 mmol) and cyclobutylamine (0.31 mL, 3.65 mmol) were stirred together with dry dichloromethane (5 mL) for 16 hours. 4-bromo-N-cyclobutyl-3-fluorobenzenesulfonamide (0.40 g, 89%) was provided after purification. MS (ESI) m/z 308. HPLC purity 98.2% at 210-370 nm, 10.6 min.; the Xterra® RP18 column, 3.5μ, 150×4.6 mm column, 1.2 mL/min., 85/15-5/95 (ammonium formate buffer pH=3.5/ACN+MeOH) for 10 min., hold 4 min.

Sources & evidence

ORD record
ord-34d0564513ea49d9814ad3c9f1314102
Source dataset
uspto-grants-2010_05
Patent number
US07723332B2

Reaction notes

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