HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → N-(2-cyanoethyl)-4-aminopiperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl 1-(2-cyanoethyl)piperidin-4-ylcarbamate | HCID 59862765 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(2-cyanoethyl)-4-aminopiperidine | HCID 22562162 | — |
Reaction Steps
TFA (1.21 g, 10.62 mmol) was added to a solution of tert-butyl [1-(2-cyanoethyl)piperidin-4-yl]carbamate (0.27 g, 1.06 mmol) in DCM (11 mL), and the mixture was stirred at rt for 2 h. The mixture was evaporated and the product was used without any further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07723333B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-db2ef7c34e3f49e3932781f1d9cc4724 |
| Source note | uspto-grants-2010_05 |