Trifluoroacetic acid → N-(2-cyanoethyl)-4-aminopiperidine

HRID 2239551Notes

Reaction equation

HRID 2239551 reaction equation
C(O)(C(F)(F)F)=O.[C:8]([CH2:10][CH2:11][N:12]1[CH2:17][CH2:16][CH:15]([NH:18]C(=O)OC(C)(C)C)[CH2:14][CH2:13]1)#[N:9]>C(Cl)Cl>[NH2:18][CH:15]1[CH2:16][CH2:17][N:12]([CH2:11][CH2:10][C:8]#[N:9])[CH2:13][CH2:14]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59862765tert-Butyl 1-(2-cyanoethyl)piperidin-4-ylcarbamate

Product 1

HCID 22562162N-(2-cyanoethyl)-4-aminopiperidine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

TFA (1.21 g, 10.62 mmol) was added to a solution of tert-butyl [1-(2-cyanoethyl)piperidin-4-yl]carbamate (0.27 g, 1.06 mmol) in DCM (11 mL), and the mixture was stirred at rt for 2 h. The mixture was evaporated and the product was used without any further purification.

Workup

  1. customThe mixture was evaporated
  2. customthe product was used without any further purification

Sources & evidence

ORD record
ord-db2ef7c34e3f49e3932781f1d9cc4724
Source dataset
uspto-grants-2010_05
Patent number
US07723333B2

Reaction notes

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