(Dimethyl sulfide)trihydroboron → 2-[4-(Trifluoromethoxy)phenyl]ethan-1-amine

2-[4-(Trifluoromethoxy)phenyl]acetamide (1.13 g, 5.156 mmol) was dissolved in THF (20 ml) and the reaction mixture was cooled in an ice-bath. Borane dimethyl sulfide complex (6.4 ml, 2M in THF) was added dropwise. After the addition, the cooling-bath was removed and the mixture was heated to reflux for 5 h and cooled down to rt. HCl (10%, 4 ml) was added, the mixture was stirred at rt overnight and then evaporated to remove THF. Water (15 ml) and diethyl ether (15 ml) were added into the residue. The two phases were separated and NaHCO3 (sat.) was added into the water phase. It was then extracted with EtOAc (20 ml×3). The extracts were combined and washed with brine, dried (Na2SO4) and evaporated. The residue was purified by column chromatography (ISOLUTE SI, 20 g/70 ml), eluting with MeOH/DCM (1:99, 2:98, 5:95 then 10:90), to give 0.2 g desired product and 0.46 g mixture. The mixture was further purified by re-chromatography (ISOLUTE SI, 20 g/70 ml), eluting with MeOH/EtOAc (2:98, 5:95, 10:90), to give 0.107 g more of the desired product. In total (0.307 g, 29%) of the title compound was obtained. Mass Spectrum: M+H+ 206. 1H NMR (400 MHz, CD3OD): δ 2.95 (t, 2H), 3.12 (t, 2H), 7.23 (d, 2H), 7.38 (d, 2H). 13C NMR (100 MHz, CD3OD): 35.3, 42.5, 122.2 (q, J=250 Hz), 122.6, 131.7, 136.2, 149.7.

1. temperaturethe reaction mixture was cooled in an ice-bath
2. additionAfter the addition
3. customthe cooling-bath was removed
4. temperaturethe mixture was heated
5. temperatureto reflux for 5 h
6. additionHCl (10%, 4 ml) was added
7. customevaporated
8. customto remove THF
9. additionWater (15 ml) and diethyl ether (15 ml) were added into the residue
10. customThe two phases were separated
11. additionNaHCO3 (sat.) was added into the water phase
12. extractionIt was then extracted with EtOAc (20 ml×3)
13. washwashed with brine
14. dry with materialdried (Na2SO4)
15. customevaporated
16. customThe residue was purified by column chromatography (ISOLUTE SI, 20 g/70 ml)
17. washeluting with MeOH/DCM (1:99, 2:98, 5:95

ORD record

ord-7ae4eecf97f94c01bb3b8569d2fb6b47

Source dataset

uspto-grants-2010_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07723333B2