Triethylamine → HCID 86611717, compound

HRID 2239827Notes

Reaction equation

HRID 2239827 reaction equation
[Cl:1][C:2]1[C:3]([Cl:12])=[C:4](Cl)[C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[N:7]=1.[CH2:13]([O:15][C:16]1[CH:22]=[CH:21][C:19]([NH2:20])=[CH:18][CH:17]=1)[CH3:14].C(N(CC)CC)C>CCO>[Cl:1][C:2]1[C:3]([Cl:12])=[C:4]([NH:20][C:19]2[CH:21]=[CH:22][C:16]([O:15][CH2:13][CH3:14])=[CH:17][CH:18]=2)[C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[N:7]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 90764-EthoxyanilineHCID 86611716HCID 86611716, compound

Product 1

HCID 86611717HCID 86611717, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

A mixture of 6,7,8-trichloroimidazo[1,2-b]pyridazine (0.04 g, 0.18 mmol) from 1d, p-ethoxyaniline (0.025 g, 0.18 mmol) and triethylamine (0.055 mL, 0.4 mmol) were suspended in EtOH (1.0 mL) and heated to 90° C. for 2.5 hours. The reaction mixture was then cooled to room temperature and concentrated in vacuo to provide crude 6,7-dichloro-N-(4-ethoxyphenyl)imidazo[1,2-b]pyridazin-8-amine (0.05 g, 86%).

Workup

  1. temperatureThe reaction mixture was then cooled to room temperature
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-a10b5f62d2cd491aa0d99cf87b55bb73
Source dataset
uspto-grants-2010_05
Patent number
US07723336B2

Reaction notes

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