反应详情

N,N-Dimethylaniline (601 mg, 4.96 mmol) was added to a suspension of 2-(methylthio)pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one (1.88 g, 10.33 mmol) from 1c in POCl3 (29 mL). The reaction mixture was heated to reflux for 7 hours, and then cooled to room temperature, concentrated in vacuo, and diluted with cold water (110 mL). The resulting solid was collected by vacuum filtration, washed with cold water and hexane, and then air dried to give 1.68 g (81%) of 4-chloro-2-(methylthio)pyrazolo[1,5-a][1,3,5]triazine.

1. temperatureThe reaction mixture was heated
2. temperatureto reflux for 7 hours
3. concentrationconcentrated in vacuo
4. additiondiluted with cold water (110 mL)
5. filtrationThe resulting solid was collected by vacuum filtration
6. washwashed with cold water and hexane
7. customair dried