Triethylamine → HCID 86611743, compound

HRID 2239865Notes

Reaction equation

[CH3:1][CH2:2][O:3][C:4]1[CH:5]=[CH:6][C:7]([NH2:10])=[CH:8][CH:9]=1.C(N(CC)CC)C.Br[C:19]1[C:20]2[N:21]([C:26]([CH3:29])=[CH:27][N:28]=2)[N:22]=[C:23]([Cl:25])[CH:24]=1.ClC1C=C(Cl)C2N(C(C)=CN=2)N=1>CCO>[Cl:25][C:23]1[CH:24]=[C:19]([NH:10][C:7]2[CH:8]=[CH:9][C:4]([O:3][CH2:2][CH3:1])=[CH:5][CH:6]=2)[C:20]2[N:21]([C:26]([CH3:29])=[CH:27][N:28]=2)[N:22]=1

Participants

Conditions

Temperature: 90 °C

Procedure

p-Phenetidine (0.068 g, 0.5 mmol) and triethylamine (0.15 ml, 1.1 mmol) were added to a mixture of 8-bromo-6-chloro-3-methylimidazo[1,2-b]pyridazine and 6,8-dichloro-3-methylimidazo[1,2-b]pyridazine (0.011 g, 0.5 mmol) both from 1a in EtOH (10 mL). The mixture was heated to 90° C. and stirred for 30 hrs. The solution was then concentrated in vacuo to give crude 6-chloro-N-(4-ethoxyphenyl)-3-methylimidazo[1,2-b]pyridazin-8-amine.

Workup

concentrationThe solution was then concentrated in vacuo

Sources & evidence

ORD record: ord-cb48709c3f6c4075b97cc510ed4de2ab
Source dataset: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07723336B2

Reaction notes

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