反应详情

温度

75 °C

0.19 g (S)-3-(4-methylphenylsulfonyloxy)-tetrahydrofuran are added to a mixture of 0.20 g 1-chloro-4-(β-D-glucopyranos-1-yl)-2-(4-hydroxybenzyl)-benzene and 0.29 g cesium carbonate in 2.5 ml dimethylformamide. The mixture is stirred at 75° C. for 4 h, before another 0.29 g caesium carbonate and 0.19 g (S)-3-(4-methylphenyl-sulfonyloxy)-tetrahydrofuran are added. After an additional 14 h stirring at 75° C. the mixture is cooled to ambient temperature, and brine is added. The resulting mixture is extracted with ethyl acetate, the combined organic extracts are dried over sodium sulfate, and the solvent is removed. The residue is purified by chromatography on silica gel (dichloromethane/methanol 1:0->5:1).

1. additionare added
2. temperatureis cooled to ambient temperature
3. extractionThe resulting mixture is extracted with ethyl acetate
4. dry with materialthe combined organic extracts are dried over sodium sulfate
5. customthe solvent is removed
6. customThe residue is purified by chromatography on silica gel (dichloromethane/methanol 1:0->5:1)