Water → HCID 178517891, compound

HRID 2240100Notes

Reaction equation

HRID 2240100 reaction equation
[C:1]1([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(S[C:16]1[N:17]=[C:18]([OH:25])[C:19]2[S:24][CH2:23][CH2:22][C:20]=2[N:21]=1)C.O>C(O)(=O)C>[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([C:16]3[N:17]=[C:18]([OH:25])[C:19]4[S:24][CH2:23][CH2:22][C:20]=4[N:21]=3)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 962WaterHCID 70961-PhenylpiperazineHCID 178477353HCID 178477353, compound

Product 1

HCID 178517891HCID 178517891, compoundYield 91.2%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
125 °C

Procedure

6.4 g (39 mmol) of N-phenylpiperazine (III) is placed in 2.2 mL of glacial acetic acid, heated to 125° C., then 3.2 g (15 mmol) of 2-ethylsulfanyl-6,7-dihydrothieno[3,2-d]pyrimidin-4-ol (II) is added, and the mixture is heated to 175° C. After 1.5 hours, the resulting solid is stirred with water, suction filtered, washed with ethanol, and dried. 4.3 g product (91%) is obtained as a powder.

Workup

  1. temperaturethe mixture is heated to 175° C
  2. filtrationfiltered
  3. washwashed with ethanol
  4. customdried

Sources & evidence

ORD record
ord-b4214ce025c9460fbb200a791800bd94
Source dataset
uspto-grants-2010_05
Patent number
US07723341B2

Reaction notes

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