Propylamine → (2-Chlorothieno[3,2-d]pyrimidin-4-yl)propylamine

HRID 2240130Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2240130
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[S:10][CH:9]=[CH:8][C:6]=2[N:7]=1.[CH2:12]([NH2:15])[CH2:13][CH3:14].C(N(C(C)C)CC)(C)C>O1CCCC1>[Cl:1][C:2]1[N:3]=[C:4]([CH2:14][CH2:13][CH2:12][NH2:15])[C:5]2[S:10][CH:9]=[CH:8][C:6]=2[N:7]=1

Komponenten

5

Edukt 3

HCID 7852PropylamineHCID 81531DiisopropylethylamineHCID 127128322,4-Dichlorothieno[3,2-d]pyrimidine

Produkt 1

HCID 86616281(2-Chlorothieno[3,2-d]pyrimidin-4-yl)propylamineAusbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

3.95 g (19.26 mmol) of 2,4-dichlorothieno[3,2-d]pyrimidine (III), 1.90 mL (23.11 mmol) of propylamine, and 6.71 mL (38.52 mmol) of diisopropylethylamine are stirred for 16 hours in 40 mL of tetrahydrofuran at ambient temperature. Then the reaction mixture is concentrated by evaporation, the residue is combined with water. The precipitate formed is suction filtered and dried. 4.03 g of product IV (92%) is obtained as a powder.

Aufarbeitung

  1. concentrationThen the reaction mixture is concentrated by evaporation
  2. customThe precipitate formed
  3. filtrationfiltered
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-e5825529f7d74da8829a9317f2a60bc9
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07723341B2

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