反应详情

To a solution of 11-(3-fluorophenyl)-9-methoxy-3,4-dihydro-2H-pyrido[1,2-b]isoquinoline-1,6-dione in 5 mL 1:1 MeOH:CH2Cl2 was added NaBH4 (17 mg). The reaction was stirred at room temp for 1 h, then diluted with bicarb and EtOAc and stirred for 30 min. The mixture was extracted once with EtOAc, and the organic solution was washed once with brine, dried (Na2SO4) and concentrated. Flash chromatography (40 g silica, 50-100% EtOAc/hexanes) gave the titled compound.

1. stirringstirred for 30 min
2. extractionThe mixture was extracted once with EtOAc
3. washthe organic solution was washed once with brine
4. dry with materialdried (Na2SO4)
5. concentrationconcentrated