Hydrogen Bromide → HCID 11243735, compound

HRID 2240201Notes

Reaction equation

HRID 2240201 reaction equation
[C:1]([C:5]1[N:6]([CH3:24])[C:7](=[O:23])[C:8]2[C:13]([C:14]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[CH:12][CH:11]=[CH:10][C:9]=2[O:21]C)([CH3:4])([CH3:3])[CH3:2].Br>>[C:1]([C:5]1[N:6]([CH3:24])[C:7](=[O:23])[C:8]2[C:13]([C:14]=1[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)=[CH:12][CH:11]=[CH:10][C:9]=2[OH:21])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 68510891HCID 68510891, compound

Product 1

HCID 11243735HCID 11243735, compound

Procedure

A mixture of 3-tert-butyl-8-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one (0.500 g) and 48% HBr (15 mL) was heated at reflux overnight. The reaction was concentrated and purified by flash chromatography (10% EtOAc in hexanes) to give the titled compound.

Workup

  1. temperaturewas heated
  2. temperatureat reflux overnight
  3. concentrationThe reaction was concentrated
  4. custompurified by flash chromatography (10% EtOAc in hexanes)

Sources & evidence

ORD record
ord-6cbad03de8254518926b257c1842c036
Source dataset
uspto-grants-2010_05
Patent number
US07723352B2

Reaction notes

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