Phosphoric Acid → 2-ethyl-6-methoxy-3-methyl-4-phenylisoquinolin-1(2H)-one
Reaction equation
F[C:2]1[CH:3]=[C:4]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([O:18][CH3:19])[CH:16]=3)[C:11](=[O:20])[N:10]([CH3:21])[C:9]=2[CH3:22])[CH:5]=[CH:6][CH:7]=1.[CH2:23](C1C=C(OC)C=CC=1C(NCC)=O)C1C=CC=CC=1.P(=O)(O)(O)O>>[CH2:21]([N:10]1[C:9]([CH3:22])=[C:8]([C:4]2[CH:5]=[CH:6][CH:7]=[CH:2][CH:3]=2)[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([O:18][CH3:19])[CH:16]=2)[C:11]1=[O:20])[CH3:23]Participants
4
Procedure
Following the procedure for 4-(3-fluorophenyl)-6-methoxy-2,3-dimethylisoquinolin-1(2H)-one (Step C), using 2-benzyl-N-ethyl-4-methoxybenzamide in place of 2-(3-fluorobenzyl)-4-methoxy-N-methylbenzamide and heating the final phosphoric acid solution to 100 C, the titled compound was synthesized.
Sources & evidence
- ORD record
- ord-25f15b8509044512afff20851c5b602f
- Source dataset
- uspto-grants-2010_05
- Patent number
- US07723352B2
Reaction notes
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