Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2240204Generated: October 30, 2026

Phosphoric Acid → 2-ethyl-6-methoxy-3-methyl-4-phenylisoquinolin-1(2H)-one

https://huagongshe.com/reaction/2240204

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhosphoric AcidHCID 1004—
Reactant4-(3-fluorophenyl)-6-methoxy-2,3-dimethylisoquinolin-1(2H)-oneHCID 11738044—
Reactant2-benzyl-N-ethyl-4-methoxybenzamideHCID 68512662—
Product2-ethyl-6-methoxy-3-methyl-4-phenylisoquinolin-1(2H)-oneHCID 11150527—

Reaction Steps

Following the procedure for 4-(3-fluorophenyl)-6-methoxy-2,3-dimethylisoquinolin-1(2H)-one (Step C), using 2-benzyl-N-ethyl-4-methoxybenzamide in place of 2-(3-fluorobenzyl)-4-methoxy-N-methylbenzamide and heating the final phosphoric acid solution to 100 C, the titled compound was synthesized.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07723352B2
Source datasetuspto-grants-2010_05
ORD IDord-25f15b8509044512afff20851c5b602f
Source noteuspto-grants-2010_05