HCID 68508262, compound → HCID 11255286, compound

HRID 2240207Notes

Reaction equation

HRID 2240207 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](=[O:13])[N:8]([CH2:14][CH2:15][NH:16]C(=O)OC(C)(C)C)[C:7]([CH3:24])=[C:6]2[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>CCOC(C)=O>[NH2:16][CH2:15][CH2:14][N:8]1[C:7]([CH3:24])=[C:6]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:5]2[C:10](=[CH:11][CH:12]=[C:3]([O:2][CH3:1])[CH:4]=2)[C:9]1=[O:13]

Participants

3

Reactant 1

HCID 68508262HCID 68508262, compound

Product 1

HCID 11255286HCID 11255286, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

tert-butyl 2-(6-methoxy-3-methyl-1-oxo-4-phenylisoquinolin-2(1H)-yl)ethylcarbamate (800 mg) was dissolved in 200 mL EtOAc and cooled to 0 C. HCl gas was bubbled through the solution for 5 min, and the reaction was warmed to room temp. After stirring for 4 h, the reaction was filtered to isolate the hydrochloride salt of the title compound as a white solid.

Workup

  1. temperaturecooled to 0 C
  2. customHCl gas was bubbled through the solution for 5 min
  3. filtrationthe reaction was filtered

Sources & evidence

ORD record
ord-a80fa2e9fa6949729117f1d57bcdcccf
Source dataset
uspto-grants-2010_05
Patent number
US07723352B2

Reaction notes

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