HCID 59304987, compound → 2-Fluoro-N1-(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)benzene-1,4-diamine

HRID 2240224Notes

Reaction equation

HRID 2240224 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[NH:11][C:12]1[C:13]2[C:20]([CH3:21])=[CH:19][NH:18][C:14]=2[N:15]=[CH:16][CH:17]=1.[H][H]>C(O)C.[Pd]>[F:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[CH:4][C:3]=1[NH:11][C:12]1[CH:17]=[CH:16][N:15]=[C:14]2[NH:18][CH:19]=[C:20]([CH3:21])[C:13]=12

Participants

5

Reactant 2

HCID 59304987HCID 59304987, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 593050112-Fluoro-N1-(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)benzene-1,4-diamine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

23 mg (80 μmol) of N-(2-fluoro-4-nitrophenyl)-3-methyl-1H-pyrrolo[2,3-b]pyridine-4-amine are dissolved in 12 ml of ethanol. 19 mg (19 μmol) of 10% palladium-on-carbon are added and the mixture is hydrogenated in a hydrogen atmosphere at atmospheric pressure overnight. The mixture is filtered through Celite and the solvent is removed under reduced pressure.

Workup

  1. filtrationThe mixture is filtered through Celite
  2. customthe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-a1e9fd35ac4643d29ccd6b2ee4b15868
Source dataset
uspto-grants-2010_05
Patent number
US07723347B2

Reaction notes

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