反应详情

A solution of 29 mg (100 μmol) of 3-methyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridine-4-amine, 33 mg (130 μmol) of 2-fluoro-1-iodo-4-nitrobenzene, 5 mg (10 μmol) of tris-(dibenzylideneacetone)dipalladium, 6 mg (10 mmol) of 1,1′-bis(diphenylphosphino)ferrocene and 14 mg (150 mmol) of sodium tert-butoxide in 3 ml of degassed toluene is stirred at 100° C. overnight. After cooling to RT, the reaction mixture is directly applied to a silica gel column and separated (mobile phase: cyclohexane/ethyl acetate 10:1 to 8:2).

1. customseparated (mobile phase: cyclohexane/ethyl acetate 10:1 to 8:2)