HCID 59305013, compound → HCID 59305021, compound

HRID 2240237Notes

Reaction equation

HRID 2240237 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]2[C:12]3[CH:19]=[CH:18][NH:17][C:13]=3[N:14]=[CH:15][CH:16]=2)=[CH:6][CH:5]=1)([O-])=O.[H][H]>C(O)C.[Pd]>[NH:17]1[C:13]2=[N:14][CH:15]=[CH:16][C:11]([NH:10][C:7]3[CH:8]=[CH:9][C:4]([NH2:1])=[CH:5][CH:6]=3)=[C:12]2[CH:19]=[CH:18]1

Participants

5

Reactant 2

HCID 59305013HCID 59305013, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 59305021HCID 59305021, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

36 mg of 10% palladium-on-carbon are added to a solution of 170 mg (0.67 mmol) of N-(4-nitrophenyl)-1H-pyrrolo[2,3-b]pyridine-4-amine in 6 ml of ethanol, and the suspension is stirred in a hydrogen atmosphere at atmospheric pressure overnight. The suspension is filtered through Celite and the Celite is washed with ethanol. Concentration under reduced pressure gives the target product.

Workup

  1. filtrationThe suspension is filtered through Celite
  2. washthe Celite is washed with ethanol
  3. concentrationConcentration under reduced pressure
  4. customgives the target product

Sources & evidence

ORD record
ord-9c055d041f9d41b2aa6a6207c3ac8c03
Source dataset
uspto-grants-2010_05
Patent number
US07723347B2

Reaction notes

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