Trifluoroacetic acid → HCID 59305030, compound

HRID 2240258Notes

Reaction equation

HRID 2240258 reaction equation
FC(F)(F)C(O)=O.[F:8][C:9]1[CH:14]=[C:13]([N+:15]([O-:17])=[O:16])[CH:12]=[CH:11][C:10]=1[NH:18][C:19]1[C:20]2[C:27]([C:28]([F:31])([F:30])[F:29])=[CH:26][N:25](COCC[Si](C)(C)C)[C:21]=2[N:22]=[CH:23][CH:24]=1>ClCCl>[F:8][C:9]1[CH:14]=[C:13]([N+:15]([O-:17])=[O:16])[CH:12]=[CH:11][C:10]=1[NH:18][C:19]1[C:20]2[C:27]([C:28]([F:31])([F:29])[F:30])=[CH:26][NH:25][C:21]=2[N:22]=[CH:23][CH:24]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59305023HCID 59305023, compound

Product 1

HCID 59305030HCID 59305030, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3 ml of trifluoroacetic acid are added to a solution of 182 mg (0.387 mmol) of N-(2-fluoro-4-nitrophenyl)-3-(trifluoromethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridine-4-amine in 3.00 ml of dichloromethane, and the mixture is stirred at RT for 30 min. The solvents are removed under reduced pressure. The residue is dissolved in ethyl acetate and washed successively with saturated solutions of sodium bicarbonate and sodium chloride, the organic phase is dried with magnesium sulfate and the solution is concentrated. The product is used without further purification.

Workup

  1. customThe solvents are removed under reduced pressure
  2. dissolutionThe residue is dissolved in ethyl acetate
  3. washwashed successively with saturated solutions of sodium bicarbonate and sodium chloride
  4. dry with materialthe organic phase is dried with magnesium sulfate
  5. concentrationthe solution is concentrated
  6. customThe product is used without further purification

Sources & evidence

ORD record
ord-bf7943718ab14e61927bd5b7319ef432
Source dataset
uspto-grants-2010_05
Patent number
US07723347B2

Reaction notes

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