反应详情

3 ml of trifluoroacetic acid are added to a solution of 182 mg (0.387 mmol) of N-(2-fluoro-4-nitrophenyl)-3-(trifluoromethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridine-4-amine in 3.00 ml of dichloromethane, and the mixture is stirred at RT for 30 min. The solvents are removed under reduced pressure. The residue is dissolved in ethyl acetate and washed successively with saturated solutions of sodium bicarbonate and sodium chloride, the organic phase is dried with magnesium sulfate and the solution is concentrated. The product is used without further purification.

1. customThe solvents are removed under reduced pressure
2. dissolutionThe residue is dissolved in ethyl acetate
3. washwashed successively with saturated solutions of sodium bicarbonate and sodium chloride
4. dry with materialthe organic phase is dried with magnesium sulfate
5. concentrationthe solution is concentrated
6. customThe product is used without further purification