Hydrochloric Acid → 1'-methylspiro[indene-1,4'-piperidin]-3(2H)-one O-methyloxime

HRID 2240398Notes

Reaction equation

[CH3:1][N:2]1[CH2:7][CH2:6][C:5]2([C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9](=O)[CH2:8]2)[CH2:4][CH2:3]1.Cl.[O:18]([NH2:20])[CH3:19]>>[CH3:19][O:18][N:20]=[C:9]1[C:10]2[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:5]2([CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]2)[CH2:8]1

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 4113O-Methylhydroxylamine

HCID 537128261'-methylspiro[indene-1,4'-piperidin]-3(2H)-one

Product 1

HCID 860822791'-methylspiro[indene-1,4'-piperidin]-3(2H)-one O-methyloxime

Procedure

The product of Example 138B and the HCl salt of methoxylamine were processed according to the method of Example 135A to provide the product. MS (ESI+) m/z 245 (M+H)+.

Workup

customto provide the product

Sources & evidence

ORD record: ord-64a2b48101f14a65be02e0088af0878a
Source dataset: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07723367B2

Reaction notes

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