m-Chloroperbenzoic acid → HCID 131728138, compound

HRID 2240552Notes

Reaction equation

HRID 2240552 reaction equation
[CH:1]1C=C(Cl)C=C(C(OO)=O)[CH:2]=1.[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([S:19]([C:22]2[C:30]3[C:25](=[CH:26][CH:27]=[C:28]([CH3:31])[CH:29]=3)[N:24]([CH2:32][C:33]([OH:35])=[O:34])[C:23]=2[CH3:36])(=O)=[O:20])=[CH:15][CH:14]=1>ClCCl>[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([S:19]([C:22]2[C:30]3[C:25](=[CH:26][CH:27]=[C:28]([CH3:31])[CH:29]=3)[N:24]([CH2:32][C:33]([O:35][CH2:1][CH3:2])=[O:34])[C:23]=2[CH3:36])=[O:20])=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acid2×HCID 104072752-[3-(4-chlorophenyl)sulfonyl-2,5-dimethylindol-1-yl]acetic acid

Product 1

HCID 131728138HCID 131728138, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

MCPBA (1.07 g) was added to a solution of example 1 part a) (1.79 g) in dichloromethane (20 ml) at 0° C. The reaction mixture was stirred for 1 h, after which further mCPBA (53 mg) was added and stirred for a further 30 min. The reaction mixture was allowed to reach room temperature and the sub-title compound was obtained as a white solid after filtration (0.68 g). Used directly in the next step without further purification.

Workup

  1. stirringstirred for a further 30 min
  2. customto reach room temperature

Sources & evidence

ORD record
ord-b806f6db6eaa43c296c15ab2eef30078
Source dataset
uspto-grants-2010_05
Patent number
US07723373B2

Reaction notes

Loading…