Iodine → HCID 131728140, compound

HRID 2240559Notes

Reaction equation

HRID 2240559 reaction equation
II.[CH3:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[SH:10].COC1C=CC(S([C:22]2[C:30]3[C:25](=[CH:26][CH:27]=[C:28]([CH3:31])[CH:29]=3)[N:24]([CH2:32][C:33]([OH:35])=[O:34])[C:23]=2[CH3:36])(=O)=O)=CC=1>CN(C=O)C>[NH4+:24].[CH3:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[S:10][C:22]1[C:30]2[C:25](=[CH:26][CH:27]=[C:28]([CH3:31])[CH:29]=2)[N:24]([CH2:32][C:33]([O-:35])=[O:34])[C:23]=1[CH3:36]

Participants

5

Reactant 3

HCID 807IodineHCID 87122-ThiocresolHCID 10067946HCID 10067946, compound

Product 1

HCID 131728140HCID 131728140, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Iodine (0.29 g) was added to a solution of 2-methylbenzenethiol (0.16 g) and the product from example 13 step a) (0.2 g) in DMF (5 ml). After 1 h the solution was purified by reverse phase HPLC. The solvent was evaporated in vacuo and the oily residue treated with ether to give a solid. Filtered off and dried to yield the title compound as a white solid (0.19 g).

Workup

  1. customAfter 1 h the solution was purified by reverse phase HPLC
  2. customThe solvent was evaporated in vacuo
  3. additionthe oily residue treated with ether
  4. customto give a solid
  5. filtrationFiltered off
  6. customdried

Sources & evidence

ORD record
ord-4610bdf271fa41d6a3e0a6ca915f9263
Source dataset
uspto-grants-2010_05
Patent number
US07723373B2

Reaction notes

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