Iodine → HCID 131728141, compound

HRID 2240560Notes

Reaction equation

HRID 2240560 reaction equation
II.[CH2:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[SH:11])[CH3:4].COC1C=CC(S([C:23]2[C:31]3[C:26](=[CH:27][CH:28]=[C:29]([CH3:32])[CH:30]=3)[N:25]([CH2:33][C:34]([OH:36])=[O:35])[C:24]=2[CH3:37])(=O)=O)=CC=1>CN(C=O)C>[NH4+:25].[CH2:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[S:11][C:23]1[C:31]2[C:26](=[CH:27][CH:28]=[C:29]([CH3:32])[CH:30]=2)[N:25]([CH2:33][C:34]([O-:36])=[O:35])[C:24]=1[CH3:37])[CH3:4]

Participants

5

Reactant 3

HCID 807IodineHCID 37343382-EthylbenzenethiolHCID 10067946HCID 10067946, compound

Product 1

HCID 131728141HCID 131728141, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Iodine (0.44 g) was added to a solution of 2-ethylbenzenethiol (0.32 g) and the product from example 13 step a) (0.2 g) in DMF (5 ml). After 1 h the solution was purified by reverse phase HPLC. The solvent was evaporated in vacuo and the oily residue treated with ether to give a solid. Filtered off and dried to yield the title compound as a white solid (0.18 g).

Workup

  1. customAfter 1 h the solution was purified by reverse phase HPLC
  2. customThe solvent was evaporated in vacuo
  3. additionthe oily residue treated with ether
  4. customto give a solid
  5. filtrationFiltered off
  6. customdried

Sources & evidence

ORD record
ord-9f43813c94fd4c10b097580183cb2192
Source dataset
uspto-grants-2010_05
Patent number
US07723373B2

Reaction notes

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