反应详情

温度

0 °C

1.24 g of 3-p-tolyl-propionic acid methyl ester (40ab) prepared by above Step 2 was dissolved in 100 ml of tetrahydrofuran under Ar atmosphere. Then 27 ml of lithium aluminium-hydride was added thereto with stirring for 2 hrs at 0° C. After 3 ml of distilled water, 3 ml of NaOH (1N) and 9 ml of distilled water were added to the reaction mixture sequentially, the mixture was stirred for 30 min and filtered using cellite in glass filter and concentrated in vacuo. The resultant was purified by Silica gel column chromatography with a solvent mixture mixed with methanol and chloroform (1:2) as an eluant to give 971 mg of 3-p-tolyl-propane-1-ol (40ac) (yield: 93%).

1. additionThen 27 ml of lithium aluminium-hydride was added
2. stirringthe mixture was stirred for 30 min
3. filtrationfiltered
4. filtrationfilter
5. concentrationconcentrated in vacuo
6. customThe resultant was purified by Silica gel column chromatography with a solvent mixture
7. additionmixed with methanol and chloroform (1:2) as an eluant