HCID 57443433, compound → HCID 57443434, compound

HRID 2240604Notes

Reaction equation

HRID 2240604 reaction equation
[CH3:1][O:2][C:3](=[O:25])[CH2:4][CH2:5][CH2:6][C:7]([C:9](=[O:24])[N:10]([CH2:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=1)[CH2:11][CH2:12][CH:13]=C)=C>C(Cl)Cl.[Ru]>[CH3:1][O:2][C:3](=[O:25])[CH2:4][CH2:5][CH2:6][C:7]1[C:9](=[O:24])[N:10]([CH2:15][C:16]2[CH:17]=[CH:18][C:19]([O:22][CH3:23])=[CH:20][CH:21]=2)[CH2:11][CH2:12][CH:13]=1

Participants

4

Reactant 1

HCID 57443433HCID 57443433, compound

Product 1

HCID 57443434HCID 57443434, compound

Reagents, catalysts & solvents 2

HCID 23950RutheniumCatalystHCID 6344DichloromethaneSolvent

Procedure

5-[(4-methoxy-benzyl)-but-3-enyl-carbamoyl]-hex-5-enoic acid methyl ester (t) prepared by above Step 1 was added to the catalyst solution containing Grubb's (I) catalysis such as ruthenium dissolved in organic solvent such as CH2Cl2 to give 4-[1-(4-methoxy-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-butyric acid methyl ester (u).

Workup

  1. additionwas added to the catalyst solution

Sources & evidence

ORD record
ord-5ccafd34e2bc498c8d518b3dc7bda863
Source dataset
uspto-grants-2010_05
Patent number
US07723376B2

Reaction notes

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