反应详情

To a mixture comprising DMF (200 ml), 5-t-butoxycarbonylaminosalicylic acid (4.37 g, 17.3 mmol) and 4-nitrooxybutyl p-toluenesulfonate (5 g, 17.3 mmol), at room temperature and under stirring triethylamine was added (2,6 ml; 19 mmol). The reaction mixture was maintained 3 days under stirring at room temperature. It was then poured in water and extracted with ethyl ether. The combined organic phases were washed with a sodium carbonate solution and then with water. After drying on sodium sulfate, the evaporation of the solvent yields a raw product that purified by silica gel chromatography gives the title compounds with a yield of 65%.

1. temperatureThe reaction mixture was maintained 3 days
2. extractionextracted with ethyl ether
3. washThe combined organic phases were washed with a sodium carbonate solution
4. customAfter drying on sodium sulfate
5. customthe evaporation of the solvent
6. customyields a raw product
7. customthat purified by silica gel chromatography