1-Bromo-4-chlorobutane → 1-(4-chlorobutyl)-3,4-dihydro-1H-benzo[b]azepine-2,5-dione

HRID 2240617Notes

Reaction equation

HRID 2240617 reaction equation
[NH:1]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[C:5](=[O:12])[CH2:4][CH2:3][C:2]1=[O:13].Br[CH2:15][CH2:16][CH2:17][CH2:18][Cl:19]>>[Cl:19][CH2:18][CH2:17][CH2:16][CH2:15][N:1]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[C:5](=[O:12])[CH2:4][CH2:3][C:2]1=[O:13]

Participants

3

Reactant 2

HCID 813641-Bromo-4-chlorobutaneHCID 3693982,3,4,5-tetrahydro-1H-1-benzazepine-2,5-dione

Product 1

HCID 685828961-(4-chlorobutyl)-3,4-dihydro-1H-benzo[b]azepine-2,5-dioneYield 58.7%

Procedure

Analogously to the procedure described in Example 1, reaction of 3,4-dihydro-1H-1-benzazepine-2,5-dione (11.42 mmol, 2.00 g) and bromo-4-chlorobutane (13.7 mmol, 2.35 g) afforded 1.78 g of the title compound, contaminated with reactants to an extent of 30%. The mixture thus obtained was reacted without further purification.

Sources & evidence

ORD record
ord-35b427160ee44b929cdb473371283abc
Source dataset
uspto-grants-2010_05
Patent number
US07723384B2

Reaction notes

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