1-Bromo-4-chlorobutane → 1-(4-Chlorobutyl)-7,8-dimethoxy-3,4-dihydro-1H-1-benzazepine-2,5-dione

HRID 2240619Notes

Reaction equation

HRID 2240619 reaction equation
[CH3:1][O:2][C:3]1[C:4]([O:16][CH3:17])=[CH:5][C:6]2[NH:12][C:11](=[O:13])[CH2:10][CH2:9][C:8](=[O:14])[C:7]=2[CH:15]=1.Br[CH2:19][CH2:20][CH2:21][CH2:22][Cl:23]>>[Cl:23][CH2:22][CH2:21][CH2:20][CH2:19][N:12]1[C:6]2[CH:5]=[C:4]([O:16][CH3:17])[C:3]([O:2][CH3:1])=[CH:15][C:7]=2[C:8](=[O:14])[CH2:9][CH2:10][C:11]1=[O:13]

Participants

3

Reactant 2

HCID 813641-Bromo-4-chlorobutaneHCID 230000647,8-dimethoxy-3,4-dihydro-1H-1-benzazepine-2,5-dione

Product 1

HCID 685831561-(4-Chlorobutyl)-7,8-dimethoxy-3,4-dihydro-1H-1-benzazepine-2,5-dioneYield 36.1%

Procedure

Analogously to Example 1, reaction of 7,8-dimethoxy-3,4-dihydro-1H-1-benzazepine-2,5-dione (1.70 mmol, 0.40 g, preparation according to Arch. Pharm. 1991, 324, 579) and bromo-4-chlorobutane (2.04 mmol, 0.35 g) afforded 0.20 g of the contaminated title compound. The compound is reacted further without purification.

Sources & evidence

ORD record
ord-4a217386314b4a54950ba8c21500f7a6
Source dataset
uspto-grants-2010_05
Patent number
US07723384B2

Reaction notes

Loading…