2-tert-Butyl-4-cyclobutyl-6-(piperazin-1-yl)pyrimidine → HCID 68583918, compound

HRID 2240620Notes

Reaction equation

HRID 2240620 reaction equation
[C:1]([C:5]1[N:10]=[C:9]([CH:11]2[CH2:14][CH2:13][CH2:12]2)[CH:8]=[C:7]([N:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[N:6]=1)([CH3:4])([CH3:3])[CH3:2].[Cl:21][CH2:22][CH2:23][CH2:24][CH2:25][N:26]1[C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=2[C:30](=[O:37])[CH2:29][CH2:28][C:27]1=[O:38]>>[ClH:21].[C:1]([C:5]1[N:6]=[C:7]([N:15]2[CH2:20][CH2:19][N:18]([CH2:22][CH2:23][CH2:24][CH2:25][N:26]3[C:32]4[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=4[C:30](=[O:37])[CH2:29][CH2:28][C:27]3=[O:38])[CH2:17][CH2:16]2)[CH:8]=[C:9]([CH:11]2[CH2:12][CH2:13][CH2:14]2)[N:10]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 666733902-tert-Butyl-4-cyclobutyl-6-(piperazin-1-yl)pyrimidineHCID 685828961-(4-chlorobutyl)-3,4-dihydro-1H-benzo[b]azepine-2,5-dione

Product 1

HCID 68583918HCID 68583918, compound

Procedure

Analogously to Example 3b, reaction of 2-tert-butyl-4-cyclobutyl-6-piperazin-1-ylpyrimidine (1.97 mmol, 0.54 g) with 1-(4-chlorobutyl)-3,4-dihydro-1H-1-benzazepine-2,5-dione afforded 0.39 g of the title compound.

Sources & evidence

ORD record
ord-4af34a43263e41678ddd93a66c5da859
Source dataset
uspto-grants-2010_05
Patent number
US07723384B2

Reaction notes

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