2-Tert-butyl-4-methyl-6-piperazin-1-ylpyrimidine → 1-{4-[4-(2-tert-Butyl-6-methylpyrimidin-4-yl)piperazin-1-yl]butyl}-3,4-dihydro-1H-1-benzazepine-2,5-dione hydrochloride

HRID 2240621Notes

Reaction equation

HRID 2240621 reaction equation
[C:1]([C:5]1[N:10]=[C:9]([CH3:11])[CH:8]=[C:7]([N:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[N:6]=1)([CH3:4])([CH3:3])[CH3:2].[Cl:18][CH2:19][CH2:20][CH2:21][CH2:22][N:23]1[C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=2[C:27](=[O:34])[CH2:26][CH2:25][C:24]1=[O:35]>>[ClH:18].[C:1]([C:5]1[N:6]=[C:7]([N:12]2[CH2:13][CH2:14][N:15]([CH2:19][CH2:20][CH2:21][CH2:22][N:23]3[C:29]4[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=4[C:27](=[O:34])[CH2:26][CH2:25][C:24]3=[O:35])[CH2:16][CH2:17]2)[CH:8]=[C:9]([CH3:11])[N:10]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 223498732-Tert-butyl-4-methyl-6-piperazin-1-ylpyrimidineHCID 685828961-(4-chlorobutyl)-3,4-dihydro-1H-benzo[b]azepine-2,5-dione

Product 1

HCID 685848231-{4-[4-(2-tert-Butyl-6-methylpyrimidin-4-yl)piperazin-1-yl]butyl}-3,4-dihydro-1H-1-benzazepine-2,5-dione hydrochloride

Procedure

Analogously to Example 3b, reaction of 2-tert-butyl-4-methyl-6-piperazin-1-ylpyrimidine (1.97 mmol, 0.46 g) with 1-(4-chlorobutyl)-3,4-dihydro-1H-1-benzazepine-2,5-dione afforded 0.31 g of the title compound.

Sources & evidence

ORD record
ord-146d01b4f34d414a9defac89a27caed7
Source dataset
uspto-grants-2010_05
Patent number
US07723384B2

Reaction notes

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