HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Tert-butyl-4-methyl-6-piperazin-1-ylpyrimidine → 1-{4-[4-(2-tert-Butyl-6-methylpyrimidin-4-yl)piperazin-1-yl]butyl}-3,4-dihydro-1H-1-benzazepine-2,5-dione hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Tert-butyl-4-methyl-6-piperazin-1-ylpyrimidine | HCID 22349873 | — |
| Reactant | 1-(4-chlorobutyl)-3,4-dihydro-1H-benzo[b]azepine-2,5-dione | HCID 68582896 | — |
| Product | 1-{4-[4-(2-tert-Butyl-6-methylpyrimidin-4-yl)piperazin-1-yl]butyl}-3,4-dihydro-1H-1-benzazepine-2,5-dione hydrochloride | HCID 68584823 | — |
Reaction Steps
Analogously to Example 3b, reaction of 2-tert-butyl-4-methyl-6-piperazin-1-ylpyrimidine (1.97 mmol, 0.46 g) with 1-(4-chlorobutyl)-3,4-dihydro-1H-1-benzazepine-2,5-dione afforded 0.31 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07723384B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-146d01b4f34d414a9defac89a27caed7 |
| Source note | uspto-grants-2010_05 |