2,4-Di-tert-butyl-6-piperazin-1-ylpyrimidine → 1-{4-[4-(2,6-Di-tert-butylpyrimidin-4-yl)piperazin-1-yl]butyl}-3,4-dihydro-1H-1-benzazepine-2,5-dione hydrochloride

HRID 2240622Notes

Reaction equation

HRID 2240622 reaction equation
[C:1]([C:5]1[N:10]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:8]=[C:7]([N:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[N:6]=1)([CH3:4])([CH3:3])[CH3:2].[Cl:21][CH2:22][CH2:23][CH2:24][CH2:25][N:26]1[C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=2[C:30](=[O:37])[CH2:29][CH2:28][C:27]1=[O:38]>>[ClH:21].[C:1]([C:5]1[N:6]=[C:7]([N:15]2[CH2:16][CH2:17][N:18]([CH2:22][CH2:23][CH2:24][CH2:25][N:26]3[C:32]4[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=4[C:30](=[O:37])[CH2:29][CH2:28][C:27]3=[O:38])[CH2:19][CH2:20]2)[CH:8]=[C:9]([C:11]([CH3:13])([CH3:14])[CH3:12])[N:10]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 114600842,4-Di-tert-butyl-6-piperazin-1-ylpyrimidineHCID 685828961-(4-chlorobutyl)-3,4-dihydro-1H-benzo[b]azepine-2,5-dione

Product 1

HCID 685831511-{4-[4-(2,6-Di-tert-butylpyrimidin-4-yl)piperazin-1-yl]butyl}-3,4-dihydro-1H-1-benzazepine-2,5-dione hydrochloride

Procedure

Analogously to Example 3b, reaction of 2,4-di-tert-butyl-6-piperazin-1-ylpyrimidine (1.26 mmol, 0.35 g) with 1-(4-chlorobutyl)-3,4-dihydro-1H-1-benzazepine-2,5-dione afforded 0.04 g of the title compound.

Sources & evidence

ORD record
ord-cffaf88a4d5b42d2a5f19383cc90998b
Source dataset
uspto-grants-2010_05
Patent number
US07723384B2

Reaction notes

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