2-Methylpiperazine, (S)- → 1-[4-((S)-3-Methylpiperazin-1-yl)butyl]-3,4-dihydro-1H-benzo[b]azepine-2,5-dione

HRID 2240627Notes

Reaction equation

HRID 2240627 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[C:10](=[O:17])[CH2:9][CH2:8][C:7]1=[O:18].[CH3:19][C@H:20]1[CH2:25][NH:24][CH2:23][CH2:22][NH:21]1>>[CH3:19][C@@H:20]1[NH:21][CH2:22][CH2:23][N:24]([CH2:2][CH2:3][CH2:4][CH2:5][N:6]2[C:7](=[O:18])[CH2:8][CH2:9][C:10](=[O:17])[C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]2=3)[CH2:25]1

Participants

3

Reactant 2

HCID 27342192-Methylpiperazine, (S)-HCID 685828961-(4-chlorobutyl)-3,4-dihydro-1H-benzo[b]azepine-2,5-dione

Product 1

HCID 685846341-[4-((S)-3-Methylpiperazin-1-yl)butyl]-3,4-dihydro-1H-benzo[b]azepine-2,5-dioneYield 22.5%

Procedure

Analogously to the method for Example 12b, reaction of 1-(4-chlorobutyl)-3,4-dihydro-1H-1-benzazepine-2,5-dione (0.56 mmol, 0.15 g) with (S)-(+)-2-methylpiperazine (0.54 mmol, 0.05 g) afforded 40.0 mg of the title compound.

Sources & evidence

ORD record
ord-9c47dc53d4cd4f1e85f2f9f2f624b7e7
Source dataset
uspto-grants-2010_05
Patent number
US07723384B2

Reaction notes

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