HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylpiperazine, (S)- → 1-[4-((S)-3-Methylpiperazin-1-yl)butyl]-3,4-dihydro-1H-benzo[b]azepine-2,5-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylpiperazine, (S)- | HCID 2734219 | — |
| Reactant | 1-(4-chlorobutyl)-3,4-dihydro-1H-benzo[b]azepine-2,5-dione | HCID 68582896 | — |
| Product | 1-[4-((S)-3-Methylpiperazin-1-yl)butyl]-3,4-dihydro-1H-benzo[b]azepine-2,5-dione | HCID 68584634 | 22.5% |
Reaction Steps
Analogously to the method for Example 12b, reaction of 1-(4-chlorobutyl)-3,4-dihydro-1H-1-benzazepine-2,5-dione (0.56 mmol, 0.15 g) with (S)-(+)-2-methylpiperazine (0.54 mmol, 0.05 g) afforded 40.0 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07723384B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-9c47dc53d4cd4f1e85f2f9f2f624b7e7 |
| Source note | uspto-grants-2010_05 |