Hydrochloric Acid → HCID 68583278, compound

HRID 2240630Notes

Reaction equation

HRID 2240630 reaction equation
[O:1]=[C:2]1[CH2:8][CH2:7][C:6](=[O:9])[C:5]2[CH:10]=[CH:11][CH:12]=[CH:13][C:4]=2[N:3]1[CH2:14][CH2:15][CH2:16][CH2:17][N:18]1[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]1.Cl>C(OCC)C>[N:18]1([CH2:17][CH2:16][CH2:15][CH2:14][N:3]2[C:4]3[CH:13]=[CH:12][CH:11]=[CH:10][C:5]=3[C:6](=[O:9])[CH2:7][CH2:8][C:2]2=[O:1])[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69535763HCID 69535763, compound

Product 1

HCID 68583278HCID 68583278, compoundYield 35.6%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

tert-Butyl 4-[4-(2,5-dioxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)butyl]piperazine-1-carboxylate from Example 61 (8.28 mmol, 3.44 g) in diethyl ether (40 ml) was admixed with saturated ethereal HCl (30 ml) and the mixture was stirred at room temperature for 12 h. The reaction mixture was then filtered and the resulting residue was washed with diethyl ether to obtain 0.93 g of the title compound.

Workup

  1. filtrationThe reaction mixture was then filtered
  2. washthe resulting residue was washed with diethyl ether

Sources & evidence

ORD record
ord-61beeb6e42ee4a7da76bf5e0c7627b48
Source dataset
uspto-grants-2010_05
Patent number
US07723384B2

Reaction notes

Loading…