Octahydropyrrolo(1,2-a)pyrazine → 1-[4-(Hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)butyl]-3,4-dihydro-1H-1-benzazepine-2,5-dione

HRID 2240631Notes

Reaction equation

HRID 2240631 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[C:10](=[O:17])[CH2:9][CH2:8][C:7]1=[O:18].[CH2:19]1[NH:24][CH2:23][CH2:22][N:21]2[CH2:25][CH2:26][CH2:27][CH:20]12>>[CH2:19]1[N:24]([CH2:2][CH2:3][CH2:4][CH2:5][N:6]2[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[C:10](=[O:17])[CH2:9][CH2:8][C:7]2=[O:18])[CH2:23][CH2:22][N:21]2[CH2:25][CH2:26][CH2:27][CH:20]12

Participants

3

Reactant 2

HCID 558578Octahydropyrrolo(1,2-a)pyrazineHCID 685828961-(4-chlorobutyl)-3,4-dihydro-1H-benzo[b]azepine-2,5-dione

Product 1

HCID 685838011-[4-(Hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)butyl]-3,4-dihydro-1H-1-benzazepine-2,5-dioneYield 35.2%

Procedure

Analogously to the method for Example 12b, reaction of 1-(4-chlorobutyl)-3,4-dihydro-1H-1-benzazepine-2,5-dione (0.40 mmol, 0.11 g) and octahydropyrrolo[1,2-a]pyrazine (0.40 mmol, 0.05 g) afforded 0.05 g of the title compound.

Sources & evidence

ORD record
ord-f061a8e9d5af4fb5a2b73350a3ff0dbf
Source dataset
uspto-grants-2010_05
Patent number
US07723384B2

Reaction notes

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