HCID 86615127, compound → HCID 68583400, compound

HRID 2240632Notes

Reaction equation

HRID 2240632 reaction equation
[O:1]=[C:2]1[CH2:8][CH2:7][C:6](=[O:9])[C:5]2[CH:10]=[CH:11][CH:12]=[CH:13][C:4]=2[N:3]1[CH2:14][CH2:15][CH2:16][CH2:17][N:18]1[CH2:24][C@H:23]2[C@@H:19]1[CH2:20][N:21](C(OCC1C=CC=CC=1)=O)[CH2:22]2.[H][H]>CO.[Pd]>[C@@H:23]12[CH2:24][N:18]([CH2:17][CH2:16][CH2:15][CH2:14][N:3]3[C:4]4[CH:13]=[CH:12][CH:11]=[CH:10][C:5]=4[C:6](=[O:9])[CH2:7][CH2:8][C:2]3=[O:1])[C@H:19]1[CH2:20][NH:21][CH2:22]2

Participants

5

Reactant 2

HCID 86615127HCID 86615127, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 68583400HCID 68583400, compoundYield 67.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

In the presence of Pd/C (0.01 g, 10%), benzyl (1R,5R)-6-[4-(2,5-dioxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)butyl]-3,6-diazabicyclo[3.2.0]heptane-3-carboxylate from Example 65 (0.45 mmol, 0.21 g) in methanol (7 ml) was reacted with hydrogen to obtain 0.10 g of the title compound.

Sources & evidence

ORD record
ord-7c9b68b363dd4ce7b9cb0056feb591ba
Source dataset
uspto-grants-2010_05
Patent number
US07723384B2

Reaction notes

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