1-(2,3-Dichlorophenyl)piperazine → 1-{4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl}-3,4-dihydro-1H-benzo[b]azepine-2,5-dione

HRID 2240633Notes

Reaction equation

HRID 2240633 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:12](=[O:13])[CH2:11][CH2:10][C:9](=[O:14])[C:8]2[CH:15]=[CH:16][CH:17]=[CH:18][C:7]1=2.[Cl:19][C:20]1[C:25]([Cl:26])=[CH:24][CH:23]=[CH:22][C:21]=1[N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>>[Cl:19][C:20]1[C:25]([Cl:26])=[CH:24][CH:23]=[CH:22][C:21]=1[N:27]1[CH2:32][CH2:31][N:30]([CH2:2][CH2:3][CH2:4][CH2:5][N:6]2[C:12](=[O:13])[CH2:11][CH2:10][C:9](=[O:14])[C:8]3[CH:15]=[CH:16][CH:17]=[CH:18][C:7]2=3)[CH2:29][CH2:28]1

Participants

3

Reactant 2

HCID 8518331-(2,3-Dichlorophenyl)piperazineHCID 685828961-(4-chlorobutyl)-3,4-dihydro-1H-benzo[b]azepine-2,5-dione

Product 1

HCID 685839201-{4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl}-3,4-dihydro-1H-benzo[b]azepine-2,5-dione

Procedure

Analogously to Example 3b, reaction of 1-(4-chlorobutyl)-3,4-dihydro-1H-benzo[b]azepine-2,5-dione with 1-(2,3-dichlorophenyl)piperazine afforded the title compound.

Sources & evidence

ORD record
ord-3185389a5e0441c6a1bb7a3281d2f5ea
Source dataset
uspto-grants-2010_05
Patent number
US07723384B2

Reaction notes

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