Piperidine → HCID 59305523, compound

HRID 2240662Notes

Reaction equation

HRID 2240662 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:41]=[CH:40][C:11]([CH2:12][C:13]3[N:14]([C:26]4[CH:31]=[CH:30][C:29]([N:32]5[S:36](=[O:38])(=[O:37])[NH:35][C:34](=[O:39])[CH2:33]5)=[CH:28][CH:27]=4)[CH:15]=[C:16]([C:18]4[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:19]=4[Cl:25])[N:17]=3)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[NH:42]1[CH2:47][CH2:46][CH2:45][CH2:44][CH2:43]1>>[Cl:25][C:19]1[CH:20]=[C:21]([Cl:24])[CH:22]=[CH:23][C:18]=1[C:16]1[N:17]=[C:13]([CH2:12][C:11]2[CH:40]=[CH:41][C:8]([C:5]3[CH:4]=[CH:3][C:2]([N:42]4[CH2:47][CH2:46][CH2:45][CH2:44][CH2:43]4)=[N:7][CH:6]=3)=[CH:9][CH:10]=2)[N:14]([C:26]2[CH:31]=[CH:30][C:29]([N:32]3[S:36](=[O:38])(=[O:37])[NH:35][C:34](=[O:39])[CH2:33]3)=[CH:28][CH:27]=2)[CH:15]=1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 59305413HCID 59305413, compound

Product 1

HCID 59305523HCID 59305523, compound

Procedure

5-{4-[2-[4-(6-Chloro-pyridin-3-yl)-benzyl]-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-phenyl}-1,2,5-thiadiazolidine-3-one-1,1-dioxide (63 mg, 0.1 mmol) was treated as described in general procedure L using piperidine (17 mg, 0.2 mmol) to give 5-(4-{4-(2,4-dichloro-phenyl)-2-[4-(3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-5′-yl)-benzyl]-imidazol-1-yl}-phenyl)-1,2,5-thiadiazolidine-3-one-1,1-dioxide.

Sources & evidence

ORD record
ord-bd03eb9048da460c9de0fe1fae45f63c
Source dataset
uspto-grants-2010_05
Patent number
US07723369B2

Reaction notes

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