Methyl bromoacetate → HCID 68582900, compound

HRID 2240722Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:32])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]([CH2:24][C:25]3[CH:30]=[CH:29][C:28]([Br:31])=[CH:27][CH:26]=3)[N:13]([C:15]3[CH:20]=[CH:19][C:18]([N+:21]([O-])=O)=[CH:17][CH:16]=3)[CH:14]=2)=[CH:6][CH:5]=1.Br[CH2:34][C:35]([O:37][CH3:38])=[O:36]>>[CH3:1][O:2][C:3](=[O:32])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]([CH2:24][C:25]3[CH:30]=[CH:29][C:28]([Br:31])=[CH:27][CH:26]=3)[N:13]([C:15]3[CH:20]=[CH:19][C:18]([NH:21][CH2:34][C:35]([O:37][CH3:38])=[O:36])=[CH:17][CH:16]=3)[CH:14]=2)=[CH:6][CH:5]=1

Participants

Reactant 2

HCID 60984Methyl bromoacetate

HCID 68583095HCID 68583095, compound

Product 1

HCID 68582900HCID 68582900, compound

Procedure

4-[2-(4-Bromo-benzyl)-1-(4-Nitro-phenyl)-1H-imidazol-4-yl]-benzoicacid methyl ester (9.8 g, 20 mmol) was reduced to amine and was reacted with methyl bromoacetate following general procedures D & E to give 4-{2-(4-Bromo-benzyl)-1-[4-(methoxycarbonylmethyl-amino)-phenyl]-1H-imidazol-4-yl}-benzoic acid methyl ester.

Sources & evidence

ORD record: ord-6445e2c014ac4786ae96fc8d844b8124
Source dataset: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07723369B2

Reaction notes

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