Benzene, 1-fluoro-2-methyl-4-nitro- → HCID 68582917, compound

HRID 2240742Notes

Reaction equation

HRID 2240742 reaction equation
[CH:1]1([C:7]2[CH:12]=[CH:11][C:10]([C:13]3[CH:18]=[CH:17][C:16]([CH2:19][C:20]4[NH:21][CH:22]=[C:23]([C:25]5[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][C:26]=5[Cl:32])[N:24]=4)=[CH:15][CH:14]=3)=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.F[C:34]1[CH:39]=[CH:38][C:37]([N+:40]([O-:42])=[O:41])=[CH:36][C:35]=1[CH3:43]>>[CH:1]1([C:7]2[CH:8]=[CH:9][C:10]([C:13]3[CH:18]=[CH:17][C:16]([CH2:19][C:20]4[N:21]([C:34]5[CH:39]=[CH:38][C:37]([N+:40]([O-:42])=[O:41])=[CH:36][C:35]=5[CH3:43])[CH:22]=[C:23]([C:25]5[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][C:26]=5[Cl:32])[N:24]=4)=[CH:15][CH:14]=3)=[CH:11][CH:12]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 68001Benzene, 1-fluoro-2-methyl-4-nitro-HCID 178477958HCID 178477958, compound

Product 1

HCID 68582917HCID 68582917, compound

Procedure

2-(4′-Cyclohexyl-biphenyl-4-ylmethyl)-4-(2,4-dichloro-phenyl)-1H-imidazole (250 mg, 0.54 mmol) was treated according to general procedure B using 2-fluoro-5-nitrotoluene to provide 2-(4′-cyclohexyl-biphenyl-4-ylmethyl)-4-(2,4-dichloro-phenyl)-1-(2-methyl-4-nitro-phenyl)-1H-imidazole, which was collected without purification. Treatment of the nitro compound as described in general procedure C provided 5-{4-[2-(4′-cyclohexyl-biphenyl-4-ylmethyl)-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-3-methyl-phenyl}-1,2,5-thiadiazolidine-3-one-1,1-dioxide.

Sources & evidence

ORD record
ord-9bd537e719dc4022bc48d18db6c845f7
Source dataset
uspto-grants-2010_05
Patent number
US07723369B2

Reaction notes

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