Benzene, 1-fluoro-2-methyl-4-nitro- → HCID 68582917, compound

Participants

Reaction Steps

2-(4′-Cyclohexyl-biphenyl-4-ylmethyl)-4-(2,4-dichloro-phenyl)-1H-imidazole (250 mg, 0.54 mmol) was treated according to general procedure B using 2-fluoro-5-nitrotoluene to provide 2-(4′-cyclohexyl-biphenyl-4-ylmethyl)-4-(2,4-dichloro-phenyl)-1-(2-methyl-4-nitro-phenyl)-1H-imidazole, which was collected without purification. Treatment of the nitro compound as described in general procedure C provided 5-{4-[2-(4′-cyclohexyl-biphenyl-4-ylmethyl)-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-3-methyl-phenyl}-1,2,5-thiadiazolidine-3-one-1,1-dioxide.

Provenance & Evidence