Trifluoroacetic acid → HCID 59305441, compound

HRID 2240753Notes

Reaction equation

C([N:5]1[C:9](=[O:10])[CH:8]=[C:7]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([N:17]3[CH:21]=[C:20]([C:22]4[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][C:23]=4[Cl:29])[N:19]=[C:18]3[CH2:30][C:31]3[CH:36]=[CH:35][C:34]([C:37]4[CH:42]=[CH:41][C:40]([O:43][CH2:44][CH:45]5[CH2:50][CH2:49][CH2:48][CH2:47][CH2:46]5)=[CH:39][CH:38]=4)=[CH:33][CH:32]=3)[CH:12]=2)[S:6]1(=[O:52])=[O:51])(C)(C)C.C(O)(C(F)(F)F)=O>>[CH:45]1([CH2:44][O:43][C:40]2[CH:39]=[CH:38][C:37]([C:34]3[CH:33]=[CH:32][C:31]([CH2:30][C:18]4[N:17]([C:13]5[CH:12]=[C:11]([C:7]6[S:6](=[O:51])(=[O:52])[NH:5][C:9](=[O:10])[CH:8]=6)[CH:16]=[CH:15][CH:14]=5)[CH:21]=[C:20]([C:22]5[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][C:23]=5[Cl:29])[N:19]=4)=[CH:36][CH:35]=3)=[CH:42][CH:41]=2)[CH2:50][CH2:49][CH2:48][CH2:47][CH2:46]1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 59305533HCID 59305533, compound

Product 1

HCID 59305441HCID 59305441, compound

Procedure

2-tert-Butyl-5-{3-[2-(4′-cyclohexylmethoxy-biphenyl-4-ylmethyl)-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-phenyl}-isothiazol-3-one-1,1-dioxide (4 mg, 0.005 mmol) was treated with TFA following general procedure to give 5-{3-[2-(4′-cyclohexylmethoxy-biphenyl-4-ylmethyl)-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-phenyl}-isothiazol-3-one-1,1-dioxide.

Sources & evidence

ORD record: ord-0b124a4a86b043d3ac32430e5eafacce
Source dataset: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07723369B2

Reaction notes

Loading…